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Friday, May 24, 2019

HED 235 - Nutrition - Experimental Design Proposal


Applying the DASH Diet to Diabetes Mellitus Type 2


Question: How does the Dietary Approaches to Stop Hypertension (DASH) diet affect patients suffering from diabetes mellitus type 2 (DM2)?

Hypothesis: A significant portion of the DASH diet consists of grains and fruits that would exacerbate diabetic patients by increasing their blood glucose level.

Methods: A pool of 1000 participants, all consisting of patients suffering from DM2 will be selected for the experiment. The patients have to be between 30 – 50 years old and the pool should have a 1:1 ratio of men and women. The pool will be divided into the experimental group and the control group leaving both groups with 500 participants (250 male and 250 female). To further eliminate possible bias from the results, the experiment will be a double blind[1], clinical trial[2]. The cover story for both the diabetic participants and the researchers on-hand will be that the experiment is trying to determine how much diabetic patients crave certain foods, as they grow older and as their hemoglobin A1c[3] level changes.

The experiment is expected to last for three years with the participants checking in with their primary care provider every three months for their routine blood check. The glucose meters of assigned to diabetic patients will also be collected to read the differences in blood glucose levels throughout the experiment. During this period, patients are expected to maintain the DASH diet provided by a stipend. Annual physical check-ups will also be done to determine if there were any benefits present elsewhere in the body. Patients in the control group will be allowed to consume a placebo[4], a random assortment of food.

Analysis: The the independent variable, in this case, is the presence of the DASH diet of fruits, vegetables, whole grains, and low-fat dairy foods. The dependent variable will be the participant’s hemoglobin A1c levels, glucose readings, and the presence of any specific improvements during annual physical check-ups. Since there are three different dependent variables, a multivariate analysis will be needed to search for any statistically significant[5] results.

Conclusion: Analysis of the DASH diet for DM2 participants indicates no significant improvements in health condition. Hemoglobin a1c levels remained constant if not elevated and glucose levels continued to spike in part due to fruit intake. The DASH diet appears ineffective in treating instances of elevated blood glucose.


[1] Both participants and researchers do not know the about the experiment or are mislead about the experiment.
[2] Study in which, one group receives experimental procedure, while the other receives the imitation treatment.
[3] Glucose attaches to hemoglobin in red blood cells and is used as an indicator of average blood glucose levels over the last 3 months.
[4] Imitation treatment design to mask the which group is receiving the actual experimental treatment + rule out the possibly of results being skewed by placebo effect.
[5] Data indicating that the connection between variables has not occurred through sheer chance.

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